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Upatrophin is a chemical introduced in Creatures 2, and also found in Creatures 3 and Docking Station. It is used to cause the creature to take a a "going-uphill" gait, and is produced when the creature is going uphill. There is also an Downatrophin which is the converse of Upatrophin. In the original Creatures 2 genome, the Upatrophin and Downatrophin were swapped, leading to creatures trying to use the 'uphill' walk when walking downhill, leading to mobility problems.