Medicine One is a chemical in Creatures 3 which reacts with ATP Decoupler to cure it. However, ATP Decoupler is so fast-acting that it is difficult to administer Medicine One in time. The medicine maker in the bridge area contains a yellow ATP Decoupler Cure which contains a full mole of Medicine One, and a small amount of Medicine One in the cool purple General Cure. In Docking Station, the Yarn Fruit contain a small amount of Medicine One.
Medicine One is one of the cures that harm Toxic Norns.