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Belladonna is a toxin in Creatures 2 and Creatures 3/Docking Station.
In Creatures 2, it is said to slow down the heart organ, affecting ATP - ADP reactions, but not as badly as cyanide does.
In Creatures 3 and Docking Station, there is no natural source of belladonna. It slows energy production, and the clock rate of the regulation organ and the Constitutive Drive Maintenance organ. Belladonna will naturally decay, and a well-fed norn can survive some belladonna, but a full dose of it can kill a creature in seconds. The Toxic Mushrooms contain belladonna, among other toxins.